Heart Burn/August 2009
Acid reflux is universal and mostly silent but may cause some unusual symptoms with potentially serious consequences.
The stomach is made like the mouth and the esophagus
is made like the eye. If one puts
a drop of acidic lemon juice into one’s mouth, it causes no harm but if one puts
it in one’s eye, it causes problems.
The control of
acid reflux depends upon the competence of the Lower Esophageal Sphincter. This muscle, if it remains tight, separates the stomach from the
esophagus and prevents acid from rushing up the esophagus.
When, for many reasons, the sphincter becomes lax, it allows the stomach
acid to creep up the esophagus, which in turn makes the sphincter more lax, and
thus a vicious cycle is established.
Acid reflux from the
stomach into the esophagus begins in infancy and continues till the end of
life. When stomach acidity is high
and contact time with the esophagus is prolonged, symptoms usually arise. Otherwise, the disorder tends to be silent
because our defenses—which include salivary flow and peristalsis—come to the
rescue and clear the stomach acid out of the esophagus.
The commonest
symptom of reflux is heartburn, a feeling of fire in the pit of the stomach. Other symptoms include cough, sore
throat, chest ache, and neck pain, all of which tend to be chronic and unresponsive to symptomatic remedies and treatments. A feeling of
shortness of breath associated with deep, unsatisfying sighs is a less known
manifestation. Unlike heart or
lung diseases where the shortness of breath gets worse with activity, the
pseudo-shortness-of-breath of reflux tends to get better with exercise. This simple distinction provides an
excellent clue to the cause of the shortness of breath.
Conditions that
encourage reflux are those that either cause laxity of the Lower Esophageal
Sphincter or cause an increase in abdominal pressure that can overcome the
sphincter's protection. Alcohol,
caffeine, tobacco, certain medications, and certain foods cause the sphincter
to become lax. Big meals, big
drinks, overweight, tight belts, bending at the waist, or lying down flat after
meals all cause a rise in abdominal pressure.
The most serious
consequence of reflux is a precancerous transformation of the lower esophagus
called Barrett’s Esophagus. This
condition can only be diagnosed by biopsy and may lead to cancer of the
esophagus if not properly managed.
Looking down the esophagus with a scope is the best way to screen for
this condition.
The treatment of
acid reflux is symptomatic. There
are no good medicines that help the Lower Esophageal Sphincter strengthen its
weak muscle fibers. There are, however,
medicines that reduce the stomach acidity and, by doing so, reduce the acid
burn to the esophagus. These
medicines are of thee types:
a) The antacids, or
medicines that neutralize the stomach acid but do not influence its production,
such as Malox, Mylanta, Tums, etc.
b) The Histamine-2 blockers
that reduce the acid production by acting on the stomach histamine receptors,
such as Tagamet, Pepsid, Zantac, etc.
C) The Proton Pump
Inhibitors, which inhibit the stomach proton pump that pushes acid into the
stomach, such as Prilosec, Nexium, Prevacid, etc.
Other treatments
involve avoiding the above-mentioned offenders such as alcohol, caffeine,
tobacco, big meals, big drinks, bending, lying down after a meal, etc. Elevating the head of the bed about 2-4 inches reduces reflux because stomach juices will not flow against
gravity.
What medicine to
take depends upon the severity of the acid reflux:
a) If the reflux is
episodic, then antacids taken as needed are enough. Taking baking soda (carbonate) is not a good idea because of
the high sodium content, which can cause swelling, high blood pressure, and
heart failure.
b) If the reflux is
moderate and frequent, then the Histamine-2 blockers such as Tagamet, Pepsid,
and Zantac are adequate and are best taken with meals and at bedtime.
c) If the reflux is
severe and constant, then the Proton Pump Inhibitors are the strongest
available and work best if taken before or at the beginning of meals.
Seeing the doctor is
not necessary for most people who can treat their own symptoms with the available
medicines. However, it the
symptoms prove resistant to treatment or if they progress and become chronic, then it becomes
advisable to see the doctor for proper evaluation and management.